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KMID : 0364320200450010011
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Journal of East-West Medicine
2020 Volume.45 No. 1 p.11 ~ p.21
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Effects of the mixed formulation of tamoxifen and blue honeysuckle on the pharmacokinetics profiles of tamoxifen after 7-day repeated administration in rats
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Jang Tae-Woo
Kang Su-Jin
Ku Sae-Kwang
Choi Seong-Hun
Lee Young-Joon
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Abstract
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Objectives : This study aims to evaluate the effects of co-administration of blue honeysuckle (BH) and tamoxifen on pharmacokinetics of tamoxifen after 7 days repeated administration, as a process of the comprehensive and integrative medicine.
Materials and methods : After 7 day-repeated oral treatment of 4 mg/kg of tamoxifen or tamoxifen 0.4 mg/㎖ with BH 40, 20 and 10 mg/㎖ concentration mixed formulas, the plasma was collected at 30 min before administration, 30 min, 1, 2, 3.5, 4, 6, 8 and 24 hrs, respectively. Plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, t1/2 and MRTinf) were analysis as compared witht amoxifen administered rats using noncompartmental PK data analyzer programs.
Results : Although no significant changes on the tamoxifen plasma concentrations and PK parameters were demonstrated after end of 7 day-repeated oral administration of mixed formulas consisted of tamoxifen and BH 40 or 10 mg/㎖ as compared to tamoxifen 0.4 mg/㎖ treated rats, seven day-repeated oral administration of tamoxifen and BH 20 mg/㎖ mixed formula induced significant increase of plasma tamoxifen concentrations from 30 min to 3.5 hrs after end of administration with significant increases of Cmax as compared with tamoxifen 0.4 mg/㎖ single formula treated rats, not in AUC0-t, and AUC0-inf, respectively.
Conclusion : Based on the results of the present study, 7 day-repeated oral administration of tamoxifen and BH 40, 20 or 10 mg/㎖ mixed formulas did not significantly influenced on the overall the oral bioavailability of tamoxifen, somewhat differed from the results of our previous single oral administration study, in which single oral administration of tamoxifen 0.4 mg/㎖ and BH 10 mg/㎖ mixed formulation induced decreases of the oral bioavailability of tamoxifen, but not in tamoxifen 0.4 mg/㎖ and BH 40 or 20 mg/㎖ mixed formulas.
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KEYWORD
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Tamoxifen, Blue honeysuckle, Pharmacokinetics, 7 day-repeated oral administration, Rat
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